tristanfaure.com /projects / pfee-lymphoma

Lymphoma MVP (PFEE × HCL)

Treatment-response prediction from histopathology slides — Hospices Civils de Lyon

2026 · IN PROGRESS

Stack

Python · PyTorch · I-JEPA · Foundation Models · Explainability · pytest

Key figures

Partner
HCL hospital network
Extractors
4 benchmarked (incl. I-JEPA)
Tests
36 — TDD
Goal
Co-authored paper

End-of-studies research project with the Hospices Civils de Lyon: predicting Hodgkin lymphoma treatment response from digitized histopathology slides.

Benchmarks four feature-extraction strategies on tissue patches: an ImageNet ResNet, a pathology foundation model, a from-scratch autoencoder, and I-JEPA — evaluated through linear probes with patient-level aggregation.

Explainability first: attribution maps trace every prediction back to the tissue regions that drove it — a hard requirement for clinical partners.

Built under clinical data-governance constraints (anonymization, auditability); 36 automated tests, TDD workflow. Code is private — no clinical data ever leaves the hospital pipeline.

Links

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